| Identification | Back Directory | [Name]
R-Acalabrutinib | [CAS]
1952316-43-6 | [Synonyms]
R-Acalabrutinib
Acalabrutinib enantiomer
Acalabrutinib Impurity N1
Acalabrutinib enantiomer, 10 mM in DMSO
(R)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Benzamide, 4-[8-amino-3-[(2R)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl- | [Molecular Formula]
C26H23N7O2 | [MDL Number]
MFCD30530419 | [MOL File]
1952316-43-6.mol | [Molecular Weight]
465.51 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [pka]
11.47±0.70(Predicted) | [InChIKey]
WDENQIQQYWYTPO-LJQANCHMSA-N | [SMILES]
C(NC1=NC=CC=C1)(=O)C1=CC=C(C2=C3N(C([C@H]4CCCN4C(=O)C#CC)=N2)C=CN=C3N)C=C1 |
| Hazard Information | Back Directory | [Uses]
(R)-Acalabrutinib ((R)-ACP-196) is the enantiomer of Acalabrutinib (HY-17600). (R)-Acalabrutinib is an inhibitor for Bruton’s tyrosine kinase (BTK)[1]. | [References]
[1] Rayala VVSPK, et al., A validated chiral chromatographic method for the enantiomeric separation of acalabrutinib. Chirality. 2022 Sep;34(9):1247-1256. DOI:10.1002/chir.23485 |
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Twochem Co.Ltd.
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Wuhan Topule
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http://www.topule.com/ |
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