| Identification | Back Directory | [Name]
giredestrant | [CAS]
1953133-47-5 | [Synonyms]
GDC-9545
giredestrant
GDC-9545(Giredestrant)
2H-Pyrido[3,4-b]indole-2-propanol, 1-[2,6-difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]amino]phenyl]-β,β-difluoro-1,3,4,9-tetrahydro-3-methyl-, (1R,3R)- | [Molecular Formula]
C27H31F5N4O | [MDL Number]
MFCD32710075 | [MOL File]
1953133-47-5.mol | [Molecular Weight]
522.55 |
| Chemical Properties | Back Directory | [Boiling point ]
618.8±55.0 °C(Predicted) | [density ]
1.333±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.68±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1]. | [IC 50]
ER | [References]
[1] C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes |
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| Company Name: |
Henan Alfachem Co.,Ltd.
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| Telephone: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
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