| Identification | Back Directory | [Name]
2-Propenoic acid, 3-(4-nitrophenyl)-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester, (2E)- | [CAS]
1954681-29-8 | [Synonyms]
LKY-047
2-Propenoic acid, 3-(4-nitrophenyl)-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester, (2E)- | [Molecular Formula]
C23H19NO7 | [MOL File]
1954681-29-8.mol | [Molecular Weight]
421.4 |
| Chemical Properties | Back Directory | [Boiling point ]
594.1±50.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 16.67 mg/mL (39.56 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC50 of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A[1]. | [IC 50]
CYP2J2: 1.7 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Nguyen Minh Phuc, et al. LKY-047: First Selective Inhibitor of Cytochrome P450 2J2. Drug Metab Dispos. 2017 Jul;45(7):765-769. DOI:10.1124/dmd.117.075036 |
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