| Identification | Back Directory | [Name]
SLF Exclusive | [CAS]
195513-96-3 | [Synonyms]
SLF Exclusive
IIDSDBBDZNDWCN-BJKOFHAPSA-N | [Molecular Formula]
C30H40N2O6 | [MDL Number]
MFCD12912270 | [MOL File]
195513-96-3.mol | [Molecular Weight]
524.648 |
| Chemical Properties | Back Directory | [Boiling point ]
656.9±65.0 °C(Predicted) | [density ]
1.161±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .2 mg/ml | [form ]
Oil | [pka]
4.14±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3]. | [References]
[1] Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425. DOI:10.3389/fphar.2018.01425
[2] Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95. DOI:10.1021/co200057n
[3] Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. DOI:10.1038/s41589-019-0279-5 |
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