| Identification | Back Directory | [Name]
2-FLUORO-5-NITROPHENYLACETIC ACID | [CAS]
195609-18-8 | [Synonyms]
2-FLUORO-5-NITROPHENYLACETIC
2-fluoro-5-nitrophenyl acetate
2-FLUORO-5-NITROPHENYLACETIC ACID
2-(2-fluoro-5-nitrophenyl)aceticaci
2-(2-Fluoro-5-nitrophenyl)acetic acid
Benzeneacetic acid, 2-fluoro-5-nitro-
3-(Carboxymethyl)-4-fluoronitrobenzene
2-FLUORO-5-NITROPHENYLACETIC ACID ISO 9001：2015 REACH | [EINECS(EC#)]
242-641-0 | [Molecular Formula]
C8H6FNO4 | [MDL Number]
MFCD04091773 | [MOL File]
195609-18-8.mol | [Molecular Weight]
199.14 |
| Chemical Properties | Back Directory | [Melting point ]
149-150 | [Boiling point ]
375.5±27.0 °C(Predicted) | [density ]
1.498 | [storage temp. ]
Store at room temperature | [form ]
powder | [pka]
3.76±0.10(Predicted) | [color ]
Off white to faint lemon |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow crystalline | [Uses]
2-Fluoro-5-nitrophenylacetic acid can be used to prepare thickened heterocyclic compounds as protein kinase inhibitors. | [Synthesis]
General procedure for the synthesis of 2-fluoro-5-nitrophenylacetic acid from o-fluorophenylacetic acid: o-fluorobenzoic acid (30.0 g, 0.19 mol) was dissolved in a mixed solution of concentrated sulfuric acid (50 mL) and water (10 mL). A mixed solution of fuming nitric acid (10 mL) and water (10 mL) was added slowly and dropwise at 0 °C. The reaction mixture was kept stirred at 0 °C for 30 min. Upon completion of the reaction, the resulting precipitate was collected by filtration and washed with cold water. Finally, the product was dried under vacuum to afford 2-(2-fluoro-5-nitrophenyl)acetic acid as a white solid (35.2 g, 91% yield). | [References]
[1] Patent: WO2010/91310, 2010, A1. Location in patent: Page/Page column 99
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 15, p. 2229 - 2235
[3] Tetrahedron, 2000, vol. 56, # 50, p. 9809 - 9818
[4] Patent: US2006/30609, 2006, A1. Location in patent: Page/Page column 15 |
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