| Chemical Properties | Back Directory | [Boiling point ]
778.4±60.0 °C(Predicted) | [density ]
1.297±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.85±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7. | [Uses]
YKL-1-116 is a selective and covalent inhibitor of Cdk7. YKL-1-116 does not target Cdk9, Cdk12, or Cdk13. YKL-1-116 is more potent than THZ1 (HY-80013) toward both Cdk7WT and Cdk7as, although Cdk7as is relatively resistant to this compound as well[1]. | [IC 50]
CDK7 | [References]
[1] Kalan S, et al. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Rep. 2017 Oct 10;21(2):467-481. DOI:10.1016/j.celrep.2017.09.056 |
|
|