| Identification | Back Directory | [Name]
4-[4-(Methylamino)imidazo[1,2-a]quinoxalin-1-yl]-1,2-benzenediol | [CAS]
1958290-51-1 | [Synonyms]
EAPB02303
4-[4-(Methylamino)imidazo[1,2-a]quinoxalin-1-yl]-1,2-benzenediol | [Molecular Formula]
C17H14N4O2 | [MOL File]
1958290-51-1.mol | [Molecular Weight]
306.32 |
| Chemical Properties | Back Directory | [Boiling point ]
559.1±50.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
9.17±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations[1]. | [References]
[1] Bigot K, et al. Imiqualines for pancreatic cancer: first-in-class potent and synergistic inhibitors of microtubule polymerisation[J]. Cancer Research, 2023, 83(7_Supplement): 5729-5729. |
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