| Identification | Back Directory | [Name]
CL 64855 | [CAS]
19622-55-0 | [Synonyms]
Megazol
CL 64855
Nitroimidazole thiadiazole
5-(1-Methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
1,3,4-Thiadiazol-2-amine, 5-(1-methyl-5-nitro-1H-imidazol-2-yl)- | [Molecular Formula]
C6H6N6O2S | [MDL Number]
MFCD01681912 | [MOL File]
19622-55-0.mol | [Molecular Weight]
226.22 |
| Chemical Properties | Back Directory | [Melting point ]
268-270 °C (decomp) | [Boiling point ]
532.6±42.0 °C(Predicted) | [density ]
2.00±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.97±0.10(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections[1]. | [in vivo]
Megazol (i.p. or p.o.; 20, 80 mg/kg) shows cure the acute disease in T. b. brueei infected Swiss mice[1].
Megazol alone not causes cure of mice carrying a subacute infection with involvement of the central nervous system (CNS) [1].
Megazol have remission effect combined suramin, without further relapse from the CNS[1]. | Animal Model: | Swiss mice[1] | | Dosage: | 20, 80 mg/kg | | Administration: | i.p., p.o. | | Result: | Cured infection at 20 mg/kg (i.p) and at 80 mg/kg (p.o). |
| [References]
[1] B Bouteille, et al. Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice. Acta Trop. 1995 Oct;60(2):73-80. DOI:10.1016/0001-706x(95)00109-r |
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