| Identification | Back Directory | [Name]
(S)-2-(1-CARBOXY-2-(4-[2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY]PHENYL)ETHYLAMINO)BENZOIC ACID METHYL ESTER | [CAS]
196809-22-0 | [Synonyms]
GW7845
GW-7845
GW 7845
L-Tyrosine, N-[2-(methoxycarbonyl)phenyl]-O-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-
(S)-2-(1-CARBOXY-2-(4-[2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY]PHENYL)ETHYLAMINO)BENZOIC ACID METHYL ESTER
(2S)-2-[(2-Methoxycarbonylphenyl)amino]-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid | [Molecular Formula]
C29H28N2O6 | [MDL Number]
MFCD09970352 | [MOL File]
196809-22-0.mol | [Molecular Weight]
500.54 |
| Hazard Information | Back Directory | [Uses]
GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2]. | [IC 50]
PPARγ; L-type calcium channel | [References]
[1] Thomas J Heppner, et al. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology. 2005 Jan;73(1):15-22. DOI:10.1159/000081070
[2] Jennifer J Schlezinger, et al. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. Toxicol Sci. 2007 Jul;98(1):125-36. DOI:10.1093/toxsci/kfm071
[3] N Suh, et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 1999 Nov 15;59(22):5671-3. PMID:10582681 |
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