| Identification | Back Directory | [Name]
2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE | [CAS]
19752-61-5 | [Synonyms]
IFLAB-BB F1371-0151
2,4-DI-T-BUTOXY-5-BROMO-PYRIMIDINE
2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE
5-broMo-2,4-bis(tert-butoxy)pyriMidine
5-BROMO-2,4-DI-(TERT-BUTOXY)PYRIMIDINE
5-Bromo-2,4-di-(tert-butoxy)pyrimidine 95%
5-BroMo-2,4-bis(1,1-diMethylethoxy)pyriMidine
Pyrimidine, 5-bromo-2,4-bis(1,1-dimethylethoxy)-
5-bromo-2,4-bis[(2-methylpropan-2-yl)oxy]pyrimidine
2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C12H19BrN2O2 | [MDL Number]
MFCD01927527 | [MOL File]
19752-61-5.mol | [Molecular Weight]
303.2 |
| Chemical Properties | Back Directory | [Melting point ]
58-61°C | [Boiling point ]
352.0±45.0 °C(Predicted) | [density ]
1.267±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DCM, Ethyl Acetate, Methanol | [form ]
Solid | [pka]
1.73±0.29(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
5-Bromo-2,4-bis(1,1-dimethylethoxy)pyrimidine is an intermediate in the synthesis of β-Pseudouridine (O839607), an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. | [Synthesis]
5-Bromo-2,4-dichloropyrimidine (10.0 mmol, 2.28 g) is dissolved in dry THF (50 mL). Then a solution of sodium tert-butoxide (25.0 mmol, 2.40 g) in THF (100 mL) is added dropwise at rt and the reaction mixture stirred for 5 h. The reaction is quenched with water (50 mL) and extracted with EtOAc (3 x 50 mL). Purification by flash chromatography yielded the desired product 5 as colorless solid (2.79 g, 92%). 5-Bromo-2,4-di-tert-butoxypyrimidine 5 ,Yield 2.79 g, 92%. |
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