| Chemical Properties | Back Directory | [Boiling point ]
549.553±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.361±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.198±0.20(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ONC213 is an αKGDH inhibitor that suppresses mitochondrial respiration and elevates α-ketoglutarate levels by inhibiting αKGDH activity, leading to apoptosis (Apoptosis) in AML cells. ONC213 can be used in acute myeloid leukemia research[1]. | [References]
[1] Su Y, et al. The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia. Cancer Res. 2024 Apr 1;84(7):1084-1100. DOI:10.1158/0008-5472.CAN-23-2659 |
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