| Identification | Back Directory | [Name]
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- | [CAS]
1978371-23-1 | [Synonyms]
P-CAB agent 2
Ornidazole Impurity 46
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- | [Molecular Formula]
C22H25FN2O4S | [MOL File]
1978371-23-1.mol | [Molecular Weight]
432.51 |
| Chemical Properties | Back Directory | [Boiling point ]
587.5±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
9.18±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1]. | [in vivo]
P-CAB agent 2 (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1]. | Animal Model: | 180-220 g, SPF grade, male SD rats[1] | | Dosage: | 2 mg/kg | | Administration: | P.o.; once | | Result: | Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%. |
| [References]
[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1. |
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