| Identification | Back Directory | [Name]
EphB3-IN-1 | [CAS]
1980036-18-7 | [Synonyms]
EphB3-IN-1
EphB1-IN-1
Acetamide, 2-chloro-N-[4-[(2-chloro-5-hydroxyphenyl)amino]-7-quinazolinyl]- | [Molecular Formula]
C16H12Cl2N4O2 | [MOL File]
1980036-18-7.mol | [Molecular Weight]
363.2 |
| Chemical Properties | Back Directory | [Boiling point ]
601.0±55.0 °C(Predicted) | [density ]
1.573±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.17±0.18(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively[1]. | [References]
[1] Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017 Jun 16;12(6):1499-1503. DOI:10.1021/acschembio.6b01083 |
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