| Chemical Properties | Back Directory | [Boiling point ]
577.430±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.295±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.388±0.30(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
HNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis[1]. | [References]
[1] Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181(1):107-124. DOI:10.1111/bph.16141 |
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