| Identification | Back Directory | [Name]
2-Amino-5-Acetylpyridine | [CAS]
19828-20-7 | [Synonyms]
5-ACETO-2-AMINOPYRIDINE
2-Amino-5-Acetylpyridine
3-Acetyl-6-aminopyridine
1-(6-AMINOPYRIDIN-3-YL)ETHANONE
1-(6-Amino-3-pyridinyl)-ethanone
1-(6-Amino-3-pyridinyl)-1-ethanone
1-(6-aminopyridin-3-yl)ethan-1-one
Ethanone, 1-(6-amino-3-pyridinyl)- | [Molecular Formula]
C7H8N2O | [MDL Number]
MFCD09038484 | [MOL File]
19828-20-7.mol | [Molecular Weight]
136.15 |
| Chemical Properties | Back Directory | [Boiling point ]
332℃ | [density ]
1.168 | [Fp ]
155℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
4.76±0.13(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 4 Synthesis of 1-(6-aminopyridin-3-yl)ethanone: To a 1L autoclave was added a saturated aqueous ammonia solution (750 mL) of 1-(6-chloropyridin-3-yl)ethanone (40 g, 257.10 mmol). The reaction mixture was stirred at 130°C for 10 hours. After completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio 50:1 dichloromethane/methanol) to afford the target compound 1-(6-aminopyridin-3-yl)ethanone in a yield of 33 g in 89% yield as a yellow solid. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Patent: WO2017/184547, 2017, A1. Location in patent: Paragraph 00379
[5] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 45 |
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