| Identification | Back Directory | [Name]
PGP9.5 | [CAS]
NoCAS | [Synonyms]
PARK5
PGP9.5
Uch-L1
UCHL1 human
UCHL1, His tagged human
ubiquitin thiolesterase L1
Rabbit Anti-PGP9.5 antibody
neuron cytoplasmic protein 9.5
Anti-UCHL1 antibody produced in goat
Ubiquitin carboxyl-terminal esterase L1
ubiquitin carboxyl-terminal hydrolase isozyme L1
Anti-UCHL1 (C-terminal) antibody produced in goat
Anti-PGP9.5, C-Terminal antibody produced in rabbit
Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase L1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
61 | [Safety Statements ]
53-45 | [WGK Germany ]
WGK 1 | [HS Code ]
3504009000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
cell analysis | [Biological Activity]
UCHL1 is a member of the peptidase C12 family and a thiol protease th at hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to generate the ubiquitin monomer. UCHL1 is expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in UCHL1 may be associated with Parkinson disease. The ligase and hydrolase activities of UCHL1 may play roles in proteasomal protein degradationa process critical for neuronal health. Inhibition of UCHL1 in mouse hippocampal slices reduces normal synaptic function and long-term potentiation. PKA-CREB pathway mediates the effects of UCHL1 on Amyloid-beta-induced synaptic dysfunction and Uchl1 also reversed the inhibition of CREB phosphorylation induced by Amyloid-beta. |
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Enzo Biochem Inc
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Merck KGaA
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Biosharp
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