| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- | [CAS]
1984824-54-5 | [Synonyms]
GDC-0334
2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- | [Molecular Formula]
C24H19F8N5O3S | [MOL File]
1984824-54-5.mol | [Molecular Weight]
609.49 |
| Hazard Information | Back Directory | [Uses]
GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma[1][2]. | [IC 50]
TRPA1 | [References]
[1] Estrada A, et al. 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists. WO2016128529 A1.
[2] Balestrini A, et.al A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J Exp Med. 2021 Apr 5;218(4):e20201637. DOI:10.1084/jem.20201637 |
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| Company Name: |
DC Chemicals
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| Telephone: |
021-58447131 13564518121 |
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https://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm |
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