| Identification | Back Directory | [Name]
kaempferol 3-O-sophoroside | [CAS]
19895-95-5 | [Synonyms]
-Sophoroside
Sophoraflavanoloside
Sophoraflavonoloside
Kaempferol 3-sophoroside
Kaempferol 3-β-sophoroside
kaempferol 3-O-sophoroside
KaeMpferol-3-O- sophroside
Kaempferol-3-O-β-D-sophoroside
Kaempferol 3-O-beta-sophoroside
Kaempferol 3-O-beta-D-sophoroside
Phillyrin/KaeMpferol-3-O-sophoroside
kaempferol3-O-β-D-glucosyl-(1→2)-β-D-glucoside
kaempferol 3-O-β-D-glucosyl-(1→2)-β-D-glucoside
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside
3-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-4',5,7-trihydroxyflavone
3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-4',5,7-trihydroxyflavone
3-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-4',5,7-trihydroxyflavone
4H-1-Benzopyran-4-one, 3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
3-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | [Molecular Formula]
C27H30O16 | [MDL Number]
MFCD01662713 | [MOL File]
19895-95-5.mol | [Molecular Weight]
610.52 |
| Chemical Properties | Back Directory | [Melting point ]
194-198℃ | [Boiling point ]
995.0±65.0 °C(Predicted) | [density ]
1.82 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
6.20±0.40(Predicted) | [color ]
Light Yellow | [InChIKey]
LKZDFKLGDGSGEO-CCMCOHMBNA-N |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from mulberry leaves, Hedyotis diffusa, and roses. | [Uses]
Kaempferol 3-β-Sophoroside is a derivative of Kaempferol (K100000), a plant flavonoid which play a beneficial role in human health promotion. | [Definition]
ChEBI: A kaempferol O-glucoside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage. | [in vivo]
Kaempferol 3-O-sophoroside (10 and 20 mg/kg, p.o., once daily for 20 days) binds to AMP-activated protein kinase (AMPK) to promote brain-derived neurotrophic factor (BDNF) production and autophagy enhancement in corticosterone (HY-B1618)-induced mouse depression model and chronic unpredictable mild stress (CUMS) model, ultimately achieving antidepressant effects[3].
Kaempferol 3-O-sophoroside (100 and 200 mg/kg, p.o., 30-minute administration duration) exhibits analgesic effects in the acetic acid-induced writhing mice model[4]. | Animal Model: | Acetic acid-induced writhing mice model[4] | | Dosage: | 50, 100, 200 mg/kg | | Administration: | Oral gavage (p.o.), administration duration of 30 minutes | | Result: | Caused dose-dependent inhibition of the writhing response induced by acetic acid. |
| Animal Model: | Corticosterone (HY-B1618)-induced mouse depression model; Chronic unpredictable mild stress (CUMS) model[3] | | Dosage: | 10 and 20 mg/kg | | Administration: | Oral gavage (p.o.), once per day for 20 consecutive days | | Result: | Ameliorated weight loss, dyskinesia, and hippocampal volume reduction induced by Corticosterone and CUMS. |
| [IC 50]
TLR2; TLR4 |
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