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199191-69-0

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199191-69-0 Structure

199191-69-0 Structure
IdentificationBack Directory
[Name]

Ziprasidone mesilate
[CAS]

199191-69-0
[Synonyms]

ziprasidone mesilate
ZIPRASIDONE MESYLATE
Ziprasidone mesylate trihydrate
Ziprasidone mesilate trihydrate CRS
Ziprasidone Hcl / Mesilate 138982-67-9 /
5-[2-[4-(1,2-benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one mesilate
2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-,monomethanesulfonate, trihydrate
2H-INDOL-2-ONE, 5-[2-[4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL]ETHYL]-6-CHLORO-1,3-DIHYDRO-, MONOMETHANESULFONATE, TRIHYDRATE
[Molecular Formula]

C22H31ClN4O7S2
[MDL Number]

MFCD07363968
[MOL File]

199191-69-0.mol
[Molecular Weight]

563.09
Chemical PropertiesBack Directory
[form ]

neat
[Major Application]

pharmaceutical (small molecule)
[InChIKey]

WLQZEFFFIUHSJB-UHFFFAOYSA-N
[SMILES]

C1(N2CCN(CC2)CCC2=CC3CC(=O)NC=3C=C2Cl)C2C=CC=CC=2SN=1.S(C)(O)(=O)=O.O.O.O
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
[Signal word ]

Warning
[Hazard statements ]

H317-H373
[Precautionary statements ]

P280-P302+P352-P314
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Skin Sens. 1
STOT RE 2
Hazard InformationBack Directory
[Uses]

Antipsychotic (central D2and 5HT2receptor antagonist).
[Definition]

ChEBI: The methanesulfonate trihydrate salt of ziprasidone.
[Brand name]

Geodon (Pfizer).
[in vivo]

Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
[IC 50]

Rat 5-HT2 Receptor: 0.42 nM (Ki); Rat 5-HT1A Receptor: 3.4 nM (Ki); Rat D2 Receptor: 4.8 nM (Ki)
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