| Identification | Back Directory | [Name]
6-ethyl-2,4,7,8-tetramethylpurino[7,8-a]imidazole-1,3-dione | [CAS]
19970-45-7 | [Synonyms]
SJ 403
SJ572403 (SJ403)
6-ethyl-2,4,7,8-tetramethylpurino[7,8-a]imidazole-1,3-dione
1H-Imidazo[2,1-f]purine-2,4(3H,8H)-dione, 8-ethyl-1,3,6,7-tetramethyl- (8CI) | [Molecular Formula]
C13H17N5O2 | [MDL Number]
MFCD06775837 | [MOL File]
19970-45-7.mol | [Molecular Weight]
275.31 |
| Chemical Properties | Back Directory | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 13.89 mg/mL (50.45 mM) | [form ]
Solid | [pka]
8.01±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1]. | [storage]
Store at -20°C | [References]
[1] Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1). Sci Rep. 2015 Oct 28;5:15686. DOI:10.1038/srep15686
[2] Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60(10):5003-5010. DOI:10.1021/acs.jcim.0c00381 |
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