| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, N4-[[1-(phenylmethyl)-4-piperidinyl]methyl]- | [CAS]
1997158-25-4 | [Synonyms]
AChE/BuChE-IN-4
N4-((1-Benzylpiperidin-4-yl)methyl)pyrimidine-2,4-diamine
2,4-Pyrimidinediamine, N4-[[1-(phenylmethyl)-4-piperidinyl]methyl]- | [Molecular Formula]
C17H23N5 | [MOL File]
1997158-25-4.mol | [Molecular Weight]
297.4 |
| Hazard Information | Back Directory | [Uses]
AChE/BuChE-IN-4(compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC50of 2.08 and 7.41 μM[1]. | [References]
[1] Concei??o RAD, et al. Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer's disease [published online ahead of print, 2023 Oct 5]. J Cell Biochem. 2023;10.1002/jcb.30483. DOI:10.1002/jcb.30483 |
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