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200134-22-1

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200134-22-1 Structure

200134-22-1 Structure
IdentificationBack Directory
[Name]

1-(4-ethylphenyl)-3-phenylurea
[CAS]

200134-22-1
[Synonyms]

INH14
1-(4-ethylphenyl)-3-phenylurea
Urea, N-(4-ethylphenyl)-N'-phenyl-
[Molecular Formula]

C15H16N2O
[MOL File]

200134-22-1.mol
[Molecular Weight]

240.3
Chemical PropertiesBack Directory
[Boiling point ]

296.4±19.0 °C(Predicted)
[density ]

1.185±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO:86.5(Max Conc. mg/mL);359.96(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);74.9(Max Conc. mM)
[form ]

Solid
[pka]

14.46±0.70(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
GHS07,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H319-H411-H372
[Precautionary statements ]

P273-P280-P305+P351+P338-P391-P501
Hazard InformationBack Directory
[Uses]

INH14 is an inhibitor of TLR2-mediated NF-kB activation.
[in vivo]

INH14 (5 μg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1].

Animal Model:8-week old, male, pathogen-free C57BL/6J mice[1]
Dosage:5 μg/g, one hour before Pam2CSK4 injection
Administration:I.P. for 2 hours
Result:Decreased TNFα production in mice.
[IC 50]

IKKβ: 3.59 μM (IC50); IKKα: 8.97 μM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

1-(4-ethylphenyl)-3-phenylurea(200134-22-1)1HNMR
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