| Identification | Back Directory | [Name]
1H-Indole-2,3-dione, 1-[[1-[(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-1,2,3-triazol-4-yl]methyl]- | [CAS]
2003213-07-6 | [Synonyms]
BuChE-IN-6
1H-Indole-2,3-dione, 1-[[1-[(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-1H-1,2,3-triazol-4-yl]methyl]- | [Molecular Formula]
C21H26N4O2 | [MOL File]
2003213-07-6.mol | [Molecular Weight]
366.46 |
| Hazard Information | Back Directory | [Uses]
BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ42 self-aggregation[1]. | [References]
[1] Marques CS, et al. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorg Chem. 2020 May;98:103753. DOI:10.1016/j.bioorg.2020.103753 |
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