| Identification | Back Directory | [Name]
1H-Benzimidazole-2-methanol,5-nitro-(9CI) | [CAS]
20034-00-8 | [Synonyms]
5-Nitro-2-benzimidazolemethanol
(5-Nitrobenzimidazol-2-yl)methanol
5-Nitro-1H-benziMidazole-2-Methanol
1H-BenziMidazole-2-Methanol, 6-nitro-
1H-Benzimidazole-2-methanol,5-nitro-(9CI)
(5-Nitro-1H-1,3-benzodiazol-2-yl)methanol | [Molecular Formula]
C8H7N3O3 | [MDL Number]
MFCD00462582 | [MOL File]
20034-00-8.mol | [Molecular Weight]
193.16 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C8H7N3O3/c12-4-8-9-6-2-1-5(11(13)14)3-7(6)10-8/h1-3,12H,4H2,(H,9,10) | [InChIKey]
ZJLPIDVKNQXTKN-UHFFFAOYSA-N | [SMILES]
C1(CO)NC2=CC([N+]([O-])=O)=CC=C2N=1 |
| Questions And Answer | Back Directory | [Application]
5-Nitro-1H-benzimidazole-2-methanol can be used as an organic intermediate and pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes. |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: 4-nitrophthalamide (10 mmol) was mixed with ethanoic acid (2.28 g, 30 mmol) in a reaction flask and concentrated phosphoric acid (20 mL) was added as a catalyst. The reaction mixture was heated to 130 °C and kept at reflux for 3 hours. Upon completion of the reaction, the reaction was quenched with 20% sodium hydroxide solution. The resulting 5-nitro-1H-benzimidazole-2-methanol solid product was separated and collected by filtration. | [References]
[1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 3006 - 3016
[2] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1272 - 1274
[3] Molecules, 2015, vol. 20, # 8, p. 15206 - 15223
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3689
[5] Journal of the American Chemical Society, 1957, vol. 79, p. 4391,4393 |
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