| Identification | Back Directory | [Name]
Adenosine, 5′→P′-ester with [P′(S)]-thiodiphosphoric acid ((HO)2P(O)OP(O)(OH)(SH)), sodium salt (1:3) | [CAS]
2005478-90-8 | [Synonyms]
Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium
Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
Adenosine, 5′→P′-ester with [P′(S)]-thiodiphosphoric acid ((HO)2P(O)OP(O)(OH)(SH)), sodium salt (1:3) | [Molecular Formula]
C10H15N5O9P2S.3Na |
| Hazard Information | Back Directory | [Description]
Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S) is an isomer of the sulfur-containing nucleotide derivative ADP-α-S.1 It is an inhibitor of phosphorylase kinase (Ki = 0.53 µM). Sp-ADP-α-S induces aggregation of isolated human platelets (EC50 = 20 µM).2 It induces relaxation of carbamoylcholine-precontracted guinea pig taenia coli (EC50 = 58.9 µM).3WARNING This product is not for human or veterinary use. | [References]
[1] A CHENG G M C. Competition between nucleoside diphosphates and triphosphates at the catalytic and allosteric sites of phosphorylase kinase.[J]. The Journal of Biological Chemistry, 1988, 263 12: 5543-5549.
[2] N.J. CUSACK S. M O H. EFFECTS OF RP AND SP DIASTEREOISOMERS OF ADENOSINE 5′-O-(1-THIODIPHOSPHATE) ON HUMAN PLATELETS[J]. British Journal of Pharmacology, 1981, 73 2: 409-412. DOI: 10.1111/j.1476-5381.1981.tb10437.x
[3] G. BURNSTOCK L. A M N J Cusack. Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder[J]. British Journal of Pharmacology, 1984, 82 2: 369-374. DOI: 10.1111/j.1476-5381.1984.tb10771.x |
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Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060 |
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