| Identification | Back Directory | [Name]
Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-, methanesulfonate (1:1) | [CAS]
200615-15-2 | [Synonyms]
F12640
F-12640
F 12640
Donitriptan mesilate
Donitriptan Mesylate
Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-, methanesulfonate (1:1) | [Molecular Formula]
C24H29N5O5S | [MOL File]
200615-15-2.mol | [Molecular Weight]
499.59 |
| Hazard Information | Back Directory | [Description]
Donitriptan Mesylate(also spelled Donitriptan mesilate ) is a 5-HT1B/1D agonist potentially for the treatment of migraines. | [Uses]
Donitriptan Mesylate is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. | [References]
[1] Mu?oz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91. DOI:10.1038/sj.bjp.0706839 |
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