| Identification | Back Directory | [Name]
GNE-6640 | [CAS]
2009273-60-1 | [Synonyms]
GNE-6640
USP7-IN-8
GNE-6776 HCl
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- | [Molecular Formula]
C21H21N3O2 | [MDL Number]
MFCD34167533 | [MOL File]
2009273-60-1.mol | [Molecular Weight]
347.41 |
| Chemical Properties | Back Directory | [Boiling point ]
590.1±50.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.20±0.15(Predicted) | [color ]
Off-white to brown |
| Hazard Information | Back Directory | [Uses]
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. | [Biological Activity]
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].
USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1]. | [References]
[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1. |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|