| Identification | Back Directory | [Name]
E3 ligase Ligand-Linker Conjugates 6 Free Base | [CAS]
2010159-60-9 | [Synonyms]
VH032-PEG2-NH2
S)-AHPC-PEG2-NH2
(S,R,S)-AHPC-PEG2-NH2
PROTACs Related Compound 6
VHL Ligand-Linker Conjugates 3
（S,R,S)-AHPC-acetamido-O-C2-amine HCI
(S,R. S)-AHPC-PEG2-amine hydrochloride salt
E3 ligase Ligand-Linker Conjugates 6 Free Base
(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)
(2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | [Molecular Formula]
C28H41N5O6S | [MDL Number]
MFCD31728145 | [MOL File]
2010159-60-9.mol | [Molecular Weight]
575.73 |
| Chemical Properties | Back Directory | [Boiling point ]
856.9±65.0 °C(Predicted) | [density ]
1.249±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, Methanol | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
(S, R, S)-AHPC-PEG2-amine is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG2 unit to empower drug research & discovery. It is reactive with NHS ester or carboxylic acid. | [Uses]
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1]. | [IC 50]
VHL | [References]
[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912 |
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