| Identification | Back Directory | [Name]
1H-1,2,3-Triazole-1-propanamide, 4-[[(4-fluorobenzoyl)amino]methyl]-N-hydroxy-β-(2-naphthalenylmethyl)-, (βR)- | [CAS]
2011754-00-8 | [Synonyms]
BDM44768
BDM-44768
BDM 44768
1H-1,2,3-Triazole-1-propanamide, 4-[[(4-fluorobenzoyl)amino]methyl]-N-hydroxy-β-(2-naphthalenylmethyl)-, (βR)- | [Molecular Formula]
C24H22FN5O3 | [MOL File]
2011754-00-8.mol | [Molecular Weight]
447.47 |
| Hazard Information | Back Directory | [Description]
BDM44768 is an inhibitor of insulin-degrading enzyme (IDE) that cat by inducing glucose intolerance. | [Uses]
BDM44768 is an inhibitior of IDE. BDM44768 exacerbates ER stress-induced IRE1 activation and promotes lipid accumulation in hepatocytes. BDM44768 potentiates activation of the IRE1 pathway in the liver and exacerbates liver lipid accumulation in an acute mice model of ER stress[1]. | [References]
[1] Andres M, et al. Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver. Br J Pharmacol. 2024 May 29. DOI:10.1111/bph.16436 |
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