| Chemical Properties | Back Directory | [Melting point ]
162-163 °C(Solv: methanol (67-56-1)) | [Boiling point ]
531.7±50.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.93±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
L-clausenamide is potentially for the treatment of Alzheimer's disease via multi-target effects. | [Uses]
(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)[1][2][3]. | [References]
[1] Chu S, Liu S, Duan W, et al. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect. Pharmacol Ther. 2016;162:179-187. DOI:10.1016/j.pharmthera.2016.01.002
[2] Chu SF, Zhang JT. Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action. Acta Pharm Sin B. 2014;4(6):417-423. DOI:10.1016/j.apsb.2014.10.004
[3] Hu JF, et al. Protective effect of (-)clausenamide against Abeta-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett. 2010 Oct 8;483(1):78-82. DOI:10.1016/j.neulet.2010.07.067 |
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