| Identification | Back Directory | [Name]
BAMIFYLLINE | [CAS]
2016-63-9 | [Synonyms]
8102CB
CB-8102
8102 CB
Bax-2739Z
Bamifyllin
BAMIFYLLINE
Bamiphylline
8-BENZYL-7-(2-(HYDROXYETHYL)AMINO)ETHYL)THEOPHYLLINE
8-benzyl-7-(2-(N-ethyl-2-hydroxyethylamino)ethyl)theophylline
8-benzyl-7-{2-[ethyl(2-hydroxyethyl)aMino]ethyl}-1,3-diMethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
7-[2-[Ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-1H-purine-2,6-dione
1H-Purine-2,6-dione,7-[2-[ethyl(2-hydroxyethyl)aMino]ethyl]-3,7-dihydro-1,3-diMethyl-8-(phenylMethyl)-
Bamifylline HclQ: What is
Bamifylline Hcl Q: What is the CAS Number of
Bamifylline Hcl Q: What is the storage condition of
Bamifylline Hcl | [Molecular Formula]
C20H27N5O3 | [MDL Number]
MFCD00867023 | [MOL File]
2016-63-9.mol | [Molecular Weight]
385.46 |
| Chemical Properties | Back Directory | [Melting point ]
80-80.5° | [Boiling point ]
619.0±65.0 °C(Predicted) | [density ]
1.25 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.73±0.10(Predicted) | [color ]
White to Pale Brown | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Originator]
Bamifylline,ZYF Pharm Chemical | [Uses]
Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist. | [Uses]
Bronchodilator. | [Definition]
ChEBI: Bamifylline is an oxopurine. | [Manufacturing Process]
A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300
L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24
hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture
was refluxed. After cooling to the mixture was added the water and
hydrochloric acid. The organic phase was extracted with hydrochloric acid. The
acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β-
hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with
dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl-
N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol.
Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline
was obtained by addition to the solution the hydrochloric acid; yield 81%,
melting point 185-186°C. | [Therapeutic Function]
Bronchodilator, Coronary vasodilator |
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