| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
13.06±0.70(Predicted) | [color ]
white to beige | [InChI]
1S/C18H16FN5OS/c1-10-15(26-18(22-10)24-17(20)21)12-3-2-4-14(9-12)23-16(25)11-5-7-13(19)8-6-11/h2-9H,1H3,(H,23,25)(H4,20,21,22,24) | [InChIKey]
HULFYSCAJVTAAR-UHFFFAOYSA-N | [SMILES]
Fc1ccc(cc1)C(=O)Nc2cc(ccc2)c3[s]c(nc3C)NC(=N)N |
| Hazard Information | Back Directory | [Uses]
AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2[1]. | [Biological Activity]
AZ1729 is a short chain fatty acid receptor FFA2 (GPR43) regulator th at acts as a direct allosteric agonist and as a positive allosteric modulator (PAM). AZ1729 selectively enhances Gi-mediated signaling (Gi-biased ligand)but not at those transduced by Gq/G11 pathway. | [storage]
Store at -20°C | [References]
[1] Bolognini D, Moss CE, Nilsson K, et al. A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias. J Biol Chem. 2016;291(36):18915-18931. DOI:10.1074/jbc.M116.736157 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|