| Chemical Properties | Back Directory | [Melting point ]
>300°C (lit.) | [density ]
1.036±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [color ]
White to off-white | [Optical Rotation]
[α]25/D +14.5°, c =2 in 5 M HCl | [InChI]
1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1 | [InChIKey]
ROHFNLRQFUQHCH-IQUPZBQQSA-N | [SMILES]
[13CH3][13CH]([13CH3])[13CH2][13C@H](N)[13C](O)=O | [CAS Number Unlabeled]
61-90-5 |
| Hazard Information | Back Directory | [Description]
L-LEUCINE-13C6, also known as 13C6-D-Leucine or L-?Leucine-?1,?2,?3,?4,?5,?5'-?13C6, is a fully 13C labelled D-Leucine. | [Uses]
Leucine-13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. DOI:10.1371/journal.pgen.1003857
[3] Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. DOI:10.1186/1743-7075-9-77
[4] Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. DOI:10.2337/db11-0765 |
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