| Identification | Back Directory | [Name]
Norethindrone-13C2 Solution, 100ppm | [CAS]
201741-02-8 | [Synonyms]
Norethindrone-13C2
Norethindrone-[13C2] in methanol
Norethindrone-13C2 Solution, 100ppm |
| Hazard Information | Back Directory | [Uses]
Norethindrone-13C2 (Norethisterone-13C2) is the 13C labeled Norethindrone (HY-B0554)[1]. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea[2][3][4][5]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. PMID:9532466
[3] Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. DOI:10.1016/j.jpag.2011.09.013
[4] Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. DOI:10.1006/rtph.2001.1483
[5] Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8. DOI:10.1016/0021-9150(83)90162-4 |
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