| Identification | Back Directory | [Name]
TPOP146 | [CAS]
2018300-62-2 | [Synonyms]
TPOP146
TPOP-146; TPOP 146
7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-3,5-dihydro-2H-1,4-benzoxazepine-9-carboxamide
1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)- | [Molecular Formula]
C27H35N3O5 | [MDL Number]
MFCD31382131 | [MOL File]
2018300-62-2.mol | [Molecular Weight]
481.58 |
| Chemical Properties | Back Directory | [Boiling point ]
641.8±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (207.65 mM) | [form ]
Solid | [pka]
10.68±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. | [IC 50]
CBP/p300 | [storage]
Store at -20°C | [References]
[1] Popp TA, et al. Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. DOI:10.1021/acs.jmedchem.6b00774 |
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