| Identification | Back Directory | [Name]
PTAC oxalate | [CAS]
201939-40-4 | [Synonyms]
PTAC oxalate
(1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate | [Molecular Formula]
C14H21N3O4S2 | [MDL Number]
MFCD22683846 | [MOL File]
201939-40-4.mol | [Molecular Weight]
359.46 |
| Hazard Information | Back Directory | [Uses]
PTAC Oxalate is a muscarinic receptor ligand. Shows partial agonist activity at the M2 and M4 receptors, with minor antagonistic activity at m1, m3, m5 receptors. Inhibits firing rate of dopaminergic cells. Neuroprotective product. | [in vivo]
PTAC oxalate (0.01, 0.05 mg/kg; IP) alleviates the mechanical allodynia in 0.05 mg/kg. PTAC oxalate decreases the immobility time of mice from both the sham and nerve injury groups at the dose of 0.05 mg/kg, but not at the dose of 0.01 mg/kg[2]. | Animal Model: | Mouse model of neuropathic pain[2] | | Dosage: | 0.01, 0.05 mg/kg | | Administration: | IP | | Result: | The mechanical allodynia was alleviated with 0.05 mg/kg.
At 0.05 mg/kg increased the paw withdrawal thresholds (PWTs) of the nerve-injury groups injected at day 4 after nerve injury.
At 0.01 mg/kg had no effect on the PWTs in the sham and nerve-injury groups injected at day 14 after nerve injury.
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| [IC 50]
mAChR1: 0.6 nM (Ki); mAChR2: 2.8 nM (Ki); mAChR3: 0.2 nM (Ki); mAChR4: 0.2 nM (Ki); mAChR5: 0.8 nM (Ki) |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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