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2022182-57-4

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2022182-57-4 Structure

2022182-57-4 Structure
IdentificationBack Directory
[Name]

E3 Ligand-Linker Conjugate 6
[CAS]

2022182-57-4
[Synonyms]

E3 Ligand-Linker Conjugate 6
Acetamide, N-(3-aminopropyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
[Molecular Formula]

C18H20N4O6
[MDL Number]

MFCD31812749
[MOL File]

2022182-57-4.mol
[Molecular Weight]

388.37
Chemical PropertiesBack Directory
[Boiling point ]

755.0±60.0 °C(Predicted)
[density ]

1.431±0.06 g/cm3(Predicted)
[pka]

10.68±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
[IC 50]

Cereblon
[References]

[1] Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262. DOI:10.1016/j.bmcl.2016.09.048
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