| Identification | Back Directory | [Name]
METHIOTHEPIN MALEATE | [CAS]
20229-30-5 | [Synonyms]
RO 8-6837
Metitepine
methiothepin
Methiothepine
METITEPINE MESYLATE
METHIOTHEPIN MALEATE
METHIOTHEPIN MESYLATE
8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine
(+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(
(+-)-1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiper
(+-)-10-(4-methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepi
1-[10,11-DIHYDRO-8-(METHYLTHIO)DIBENZO[B,F]THIEPIN-10-YL]-4-METHYLPIPERAZINE
Piperazine, 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-
1-[10,11-DIHYDRO-8-(METHYLTHIO)DIBENZO[B,F]THIEPIN-10-YL]-4-METHYLPIPERAZINE MALEATE
1-[10,11-DIHYDRO-8-(METHYLTHIO)DIBENZO[B,F]THIEPIN-10-YL]-4-METHYLPIPERAZINE MESYLATE
1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazinemaleate | [Molecular Formula]
C20H24N2S2 | [MDL Number]
MFCD00209930 | [MOL File]
20229-30-5.mol | [Molecular Weight]
356.55 |
| Chemical Properties | Back Directory | [Melting point ]
88-89° | [Boiling point ]
462.9±45.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
H2O: 13 mg/mL | [form ]
solid | [pka]
7.95±0.42(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
5HT1&2 receptor antagonist | [Uses]
Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist. | [Definition]
ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+). | [Biological Activity]
Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively). |
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