| Identification | Back Directory | [Name]
Myelin Oligodendrocyte Glycoprotein (35-55) amide (rat, mouse) | [CAS]
2022956-48-3 | [Synonyms]
Myelin Oligodendrocyte Glycoprotein (35-55) amide (rat, mouse)
L-Lysinamide, L-methionyl-L-α-glutamyl-L-valylglycyl-L-tryptophyl-L-tyrosyl-L-arginyl-L-seryl-L-prolyl-L-phenylalanyl-L-seryl-L-arginyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-tyrosyl-L-arginyl-L-asparaginylglycyl- | [Molecular Formula]
C118H178N36O28S | [MOL File]
2022956-48-3.mol | [Molecular Weight]
2580.97 |
| Hazard Information | Back Directory | [Uses]
MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4+ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model[1][2][3]. | [in vivo]
MOG(35-55) amide, mouse, rat (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice[2].
MOG(35-55) amide, mouse, rat (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice[3].
| Animal Model: | 129S1/SvImJ, C57BL/6 and C57BL/6 X SJL hybrid[2] | | Dosage: | 3 mg/mL, 0.1 mL per mice; accompanied with CFA and 4 mg/mL Mycobacterium tuberculosis | | Administration: | Subcutaneous injection; single dose | | Result: | Showed the expected signs of experimental autoimmune encephalomyelitis (EAE), which started with tail loss of tonus and continued in an ascending fashion in mice immunized with MOG35-55. |
| Animal Model: | C57BL/6 mice (8-12 weeks)[3] | | Dosage: | 200 μg | | Administration: | Subcutaneous injection; single dose; analyzed at pre-onset (day 7 post immunization), onset (day 9-13 post immunization) and peak (day 17-19 post immunization) | | Result: | Increased eosinophil abundance in the spinal cord increases in the course of EAE. |
| [References]
[1] Saligrama N, et al. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. 2019 Aug;572(7770):481-487. DOI:10.1038/s41586-019-1467-x
[2] Giralt M, et al. Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse. Methods Mol Biol. 2018;1791:227-232. DOI:10.1007/978-1-4939-7862-5_17
[3] Ruppova K, et al. Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice. Immunol Lett. 2021 Nov;239:72-76. DOI:10.1016/j.imlet.2021.09.001 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|