| Identification | Back Directory | [Name]
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE | [CAS]
20231-01-0 | [Synonyms]
EWP 815
4-methylpiperazino-thiuramdisulfide
4-METHYLPIPERAZINO-THIURAMDISULPHIDE
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
disulfide,bis((4-methyl-1-piperazinyl)thiocarbonyl)
Bis(4-methyl-1-piperazinylthiocarbonyl) disulfide,98%
4-Methylpiperazine-1-carbothioic dithioperoxyanhydride | [EINECS(EC#)]
247-450-6 | [Molecular Formula]
C12H22N4S4 | [MDL Number]
MFCD01729803 | [MOL File]
20231-01-0.mol | [Molecular Weight]
350.59 |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
142-143 °C
| [Boiling point ]
450.5±55.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.63±0.42(Predicted) | [color ]
White to off-white | [InChI]
1S/C12H22N4S4/c1-13-3-7-15(8-4-13)11(17)19-20-12(18)16-9-5-14(2)6-10-16/h3-10H2,1-2H3 | [InChIKey]
OOBDBFPYJXJEHC-UHFFFAOYSA-N | [SMILES]
CN1CCN(C(SSC(N2CCN(C)CC2)=S)=S)CC1 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Uses]
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2]. | [in vivo]
EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice[2].
| Animal Model: | Female mice (20 g)[2] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal injection; 30 min before killed | | Result: | Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3H-α-methyldopamine.
Reduced the amount of 3H-α-Me-NA by 12%. |
| [References]
[1] Fowler CJ, et al. Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):853-9. DOI:10.1042/bj2890853
[2] Carlsson A, et al. On the beta-hydroxylation of (+-)-alpha-methyldopamine in vivo. Eur J Pharmacol. 1968 Dec;5(1):85-92. DOI:10.1016/0014-2999(68)90160-x |
| Safety Data | Back Directory | [Safety Statements ]
24/25 | [WGK Germany ]
WGK 3 | [HS Code ]
29335995 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 oral in rat: > 5gm/kg |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Acros Organics
|
| Tel: |
+32 14/57.52.11 |
| Website: |
www.acros.be |
|