| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyridinyl]- | [CAS]
202466-77-1 | [Synonyms]
Ro63-0563
Ro 63-0563
Ro-63-0563
Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyridinyl]- | [Molecular Formula]
C13H17N5O2S | [MDL Number]
MFCD05662300 | [MOL File]
202466-77-1.mol | [Molecular Weight]
307.37 |
| Hazard Information | Back Directory | [Description]
Ro 63-0563 is a potent and selective antagonist of 5-HT6 receptors. | [Uses]
Ro 63-0563 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.83 and 7.91 for rat and human 5-HT6 receptors, respectively. Ro 63-0563 has no affinity for other receptors[1]. | [IC 50]
Rat 5-HT6 Receptor: 7.83 (pKi); Human 5-HT6 Receptor: 7.91 (pKi) | [References]
[1] Sleight A J, et al. Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT6 receptors[J]. British journal of pharmacology, 1998, 124(3): 556-562. DOI:10.1038/sj.bjp.0701851 |
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