| Identification | Back Directory | [Name]
H-TRP-PHE-TYR-SER(PO3H2)-PRO-ARG-PNA | [CAS]
202739-41-1 | [Synonyms]
H-TRP-PHE-TYR-SER(PO3H2)-PRO-ARG-PNA
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA trifluoroacetate salt
L-Argininamide, L-tryptophyl-L-phenylalanyl-L-tyrosyl-O-phosphono-L-seryl-L-prolyl-N-(4-nitrophenyl)- (9CI) | [Molecular Formula]
C49H59N12O13P | [MDL Number]
MFCD18633561 | [MOL File]
202739-41-1.mol | [Molecular Weight]
1055.04 |
| Hazard Information | Back Directory | [Uses]
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins[1][2]. | [References]
[1] M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60. DOI:10.1126/science.278.5345.1957
[2] Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65. DOI:10.1021/jm200156c |
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Ontores Biotech
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