| Identification | Back Directory | [Name]
TCO-PEG3-Amine | [CAS]
2028288-77-7 | [Synonyms]
TCO-PEG3-Amine
TCO-C3-PEG3-C3-amine
(4E)-TCO-C3-PEG3-C3-amine | [Molecular Formula]
C19H36N2O5 | [MDL Number]
MFCD30458038 | [MOL File]
2028288-77-7.mol | [Molecular Weight]
372.51 |
| Hazard Information | Back Directory | [Description]
TCO-PEG3-amine is a click chemistry crosslinking reagent. It can be used to derivatize NHS activated esters through a stable amide bond or carboxyl groups in the presence of of activators (e.g. EDC, or HATU). TCO enable click chemistry with tetrazine. PEG spacer improves water solubility. | [Uses]
TCO-C3-PEG3-C3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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