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DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor. It induces differentiation in acute myeloid leukemia. | [Uses]
DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1]. | [References]
[1] Lewis TA, et al. Development?of?ML390: A?Human?DHODH?Inhibitor?That?Induces?Differentiation?in?Acute?Myeloid?Leukemia. ACS Med Chem Lett.?2016 Sep 28;7(12):1112-1117. DOI:10.1021/acsmedchemlett.6b00316 |
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