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2029049-77-0

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2029049-77-0 Structure

2029049-77-0 Structure
IdentificationBack Directory
[Name]

DHODH-IN-7
[CAS]

2029049-77-0
[Synonyms]

DHODH-IN-7
hDHODH-IN-5
[Molecular Formula]

C21H21F3N2O2
[MDL Number]

MFCD32663082
[MOL File]

2029049-77-0.mol
[Molecular Weight]

390.4
Chemical PropertiesBack Directory
[Boiling point ]

603.0±55.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[pka]

13.44±0.46(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H335-H302-H315
[Precautionary statements ]

P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Description]

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor. It induces differentiation in acute myeloid leukemia.
[Uses]

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].
[References]

[1] Lewis TA, et al. Development?of?ML390: A?Human?DHODH?Inhibitor?That?Induces?Differentiation?in?Acute?Myeloid?Leukemia. ACS Med Chem Lett.?2016 Sep 28;7(12):1112-1117. DOI:10.1021/acsmedchemlett.6b00316
Spectrum DetailBack Directory
[Spectrum Detail]

DHODH-IN-7(2029049-77-0)1HNMR
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