| Identification | Back Directory | [Name]
Rbin-2 - Ribozinoindole-2 | [CAS]
2032282-97-4 | [Synonyms]
Rbin-2
Rbin-2 >=98% (HPLC)
Rbin-2 - Ribozinoindole-2
5H-1,2,4-Triazino[5,6-b]indole, 7-bromo-3-[(2-methyl-2-propen-1-yl)thio]- | [Molecular Formula]
C13H11BrN4S | [MOL File]
2032282-97-4.mol | [Molecular Weight]
335.22 |
| Chemical Properties | Back Directory | [Boiling point ]
524.3±60.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 1mg/mL, clear (warmed) | [form ]
Solid | [pka]
9.30±0.50(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C13H11BrN4S/c1-7(2)6-19-13-16-12-11(17-18-13)9-4-3-8(14)5-10(9)15-12/h3-5H,1,6H2,2H3,(H,15,16,18) | [InChIKey]
OVDAOBDZJJZJMY-UHFFFAOYSA-N | [SMILES]
CC(CSC(N=N1)=NC2=C1C3=C(N2)C=C(Br)C=C3)=C |
| Hazard Information | Back Directory | [Description]
Rbin-2 is a novel cell penetrant, potent, selective and reversible inhibitor of Midasin, inhibiting eukaryotic ribosome biogenesis and directly targeting AAA+ ATPase Midasin. | [Uses]
Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1]. | [References]
[1] Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14. DOI:10.1016/j.cell.2016.08.070 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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http://www.energy-chemical.com |
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Merck KGaA
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www.sigmaaldrich.cn |
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