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2036074-41-4

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2036074-41-4 Structure

2036074-41-4 Structure
IdentificationBack Directory
[Name]

AMPA Receptor Modulator-1
[CAS]

2036074-41-4
[Synonyms]

AMPA Receptor Modulator-1
AMPA receptor modulator1,AMPA receptor modulator 1
2H-Indol-2-one, 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-7-methyl-
[Molecular Formula]

C16H11ClF3NO2
[MDL Number]

MFCD31813690
[MOL File]

2036074-41-4.mol
[Molecular Weight]

341.71
Chemical PropertiesBack Directory
[Boiling point ]

391.5±42.0 °C(Predicted)
[density ]

1.394±0.06 g/cm3(Predicted)
[pka]

11.02±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5)[1].
[References]

[1] Ravula S, et al. Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. DOI:10.1021/acsmedchemlett.8b00215
Spectrum DetailBack Directory
[Spectrum Detail]

AMPA Receptor Modulator-1(2036074-41-4)1HNMR
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