| Identification | Back Directory | [Name]
JNJ-55511118 | [CAS]
2036081-86-2 | [Synonyms]
JNJ-55511118
5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one | [Molecular Formula]
C14H8ClF3N2O2 | [MDL Number]
MFCD30480932 | [MOL File]
2036081-86-2.mol | [Molecular Weight]
328.67 |
| Chemical Properties | Back Directory | [Boiling point ]
279.7±40.0 °C(Predicted) | [density ]
1.462±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:32.87(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:32.87(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
A crystalline solid | [pka]
11.77±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
JNJ 55511118 is an AMPA receptor modulator. | [Biological Activity]
JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitormainly in the hippocampus region.''JNJ-55511118 is an orally availablebrain penetrantpotent and selective negative modulator of AMPA receptors th at requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampusand a strong anti-convulsant effect. | [storage]
Store at +4°C |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|