| Identification | Back Directory | [Name]
4(3H)-Quinazolinone, 2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)- | [CAS]
2041072-41-5 | [Synonyms]
ICCB280
4(3H)-Quinazolinone, 2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)- | [Molecular Formula]
C23H18N2O4 | [MDL Number]
MFCD01852729 | [MOL File]
2041072-41-5.mol | [Molecular Weight]
386.4 |
| Chemical Properties | Back Directory | [Boiling point ]
624.1±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 83.33 mg/mL (215.66 mM) | [form ]
Solid | [pka]
9.40±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2]. | [References]
[1] Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9. DOI:10.1177/1087057115592220
[2] Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938. DOI:10.3390/molecules23081938 |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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