| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-[[5-[2-(2-propyn-1-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]- | [CAS]
2042629-43-4 | [Synonyms]
Ritlecitinib Impurity 39
2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-[[5-[2-(2-propyn-1-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]- | [Molecular Formula]
C20H25N5O2 | [MOL File]
2042629-43-4.mol | [Molecular Weight]
367.44 |
| Hazard Information | Back Directory | [Uses]
JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1]. JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110. |
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