| Identification | Back Directory | [Name]
COX-2-IN-47 | [CAS]
2043670-02-4 | [Synonyms]
COX-2-IN-47
Acetic acid, 2-[4-[4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenoxy]- | [Molecular Formula]
C18H18N2O4 | [MOL File]
2043670-02-4.mol | [Molecular Weight]
326.35 |
| Chemical Properties | Back Directory | [Boiling point ]
530.340±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.290±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
2.834±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-47 (compound 6c ) is a selective COX-2 inhibitor with IC50 value of 0.03 μM. COX-2-IN-47 has antiedema activity[1]. | [IC 50]
COX-2: 0.03 μM (IC50) | [References]
[1] Elgohary MK, et al. Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular modeling investigation. Bioorg Chem. 2024 Nov;152:107727. DOI:10.1016/j.bioorg.2024.107727 |
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